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Stem Cells and Multipotent Progenitor Cells Stem Cells and Multipotent Progenitor Cells In multicellular organisms, specific stem cell types with distinct developmental potentials occur during development.

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The presence of both characteristics in one cell is rare and sets these highly specialized cells aside from the majority of the somatic cell populations. These unique properties make stem cells ideal targets for stem cell engineering to generate cells with wanted properties.

The laboratory studies pluripotent stem cells ES cells and iPS cells and adult stem cells hematopoietic stem cells and mesenchymal stem cells. Patient and disease specific iPS cells are obtained from somatic cells by reprogramming.

Hematopoietic stem Mature in aachen are differentiated into dendritic cells.

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Stem Cell Engineering Induced pluripotent stem cells iPS cells represent engineered stem cells, which are obtained by reprogramming of somatic cells with specific sets of transcription factors, such as Oct4, Sox2, Klf4 and c-Myc.

However, frequently their differentiation potential is rather poor. We used cell fusion Mature in aachen iPS cells with hematopoietic stem cells to increase the propensity and differentiation potential of pluripotent stem cells towards hematopoietic cells and other mesendodermal lineages, such as Pussy in Hungary now, hepatocytes and endothelial cells Qin et al.

Immunogenicity of iPS cells and iPS cell-derived cells remains controversial. Sertoli cells constitute the structural framework in testis and provide Horney single mom Leesville immune-privileged environment for germ cells.

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We found that early-passage Sertoli cell-derived iPS cells retain some somatic memory of Sertoli cells that confers reduced immunogenicity of iPS cells and iPS cell-derived cells in vivo and in vitro Wang et al.

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Differentiation of human induced pluripotent stem cells iPS cells and embryonic stem cells ES cells into dendritic cell DC subsets. Sontag, S.

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